Effects of Methanolic Extract from Turmeric (Curcuma longa) against the In Vitro Multiplication of Several Babesia Species and Theileria equi

Anti-piroplasm drugs currently on the market have proven toxicity to host and parasite resistance. Plants are possible sources of novel drugs. Subsequently, a strategy should be used find new anti-piroplasm agents that both effective safe. In present study, we evaluated effect turmeric (Curcuma longa) methanolic extract in vitro growth Babesia (B.) bovis, B. divergens, caballi, Theileria (T.) equi. The inhibitory effectiveness was assessed using fluorescence test. enhancement efficacy when administrated combination with diminazene aceturate (DA) investigated cultures different piroplasm parasites. Turmeric reduced T. equi, caballi IC50 values 0.830 ± 0.078, 0.375 0.055, 1.405 0.575, 0.720 0.090 mg/mL, respectively. An amount 1 mg/mL for 0.5 exhibited 73.43%, 80.065%, 73.47%, 47.375% inhibitions parasites, When combined DA, its impact bovine equine Babesia/Theileria parasites amplified. These findings show could promising medicinal plant treatment babesiosis, especially administered conjunction DA.